I don't think it interacts with Disguise at all, but I heard something about certain articles of clothing being "marked" with your identity, and you'd need to essentially put together a set of clothing, headgear, and cloak that you only use when "infiltrating" populated places that are predisposed against you. On top of that, you'd have to regularly succeed Influence rolls against NPCs, to prevent them from becoming hostile.
I'm sure there can be a more nuanced approach through the new Disguise skill and it does seem like it would be really useful.